Ultrasound in Crohn’s Disease - bowel wall characteristics and perfusion estimates using microbubbles
نویسندگان
چکیده
....................................................................................................................................... 11 LIST OF PUBLICATIONS ............................................................................................................... 13 INTRODUCTION ................................................................................................................... 15 1. Crohn’s disease ............................................................................................................... 15 1.1 1.1.1 Background ......................................................................................................................... 15 1.1.2 Symptoms and findings ....................................................................................................... 16 1.1.3 Macroscopic and histological findings ................................................................................ 17 1.1.4 Imaging in Crohn’s disease ................................................................................................. 17 Diagnostic ultrasound ..................................................................................................... 18 1.2 1.2.1 General ................................................................................................................................ 18 1.2.2 B-mode ................................................................................................................................ 19 1.2.3 Doppler ................................................................................................................................ 20 1.2.4 Ultrasound of the GI tract .................................................................................................... 21 Contrast-enhanced ultrasound and perfusion ................................................................. 23 1.3 1.3.1 Microbubbles and contrast-enhanced ultrasound ................................................................. 23 1.3.2 Perfusion estimation with CEUS ......................................................................................... 26 AIMS OF THE STUDY .......................................................................................................... 33 2. MATERIALS AND METHODS ............................................................................................ 35 3. 3.1 Study population .............................................................................................................. 35 3.2 Clinical scores ................................................................................................................. 36 3.3 Biochemical analysis ....................................................................................................... 36
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